Abstract
The allele frequency distributions of six STR loci (D3S1358, D16S539, THOI, D8S1179, LPL, and HUMvWFII) used in forensic practice were analyzed in populations of Sakha (Yakutia): three ethnogeographical groups of Sakha (Yakuts), Evenks, Yukagirs, Dolgans, and Russians. There were significant differences between Russians and all other populations by five markers. The total discriminating power (PD) of the locus system studied was assessed for each population. The interpopulation genetic difference (F ST) was 0.005. Data on the allelic polymorphism of the above STR loci were used to analyze phylogenetic relationships among the populations of Sakha and those of other regions: East Europe, South Siberia, Chukotka, and Kamchatka.
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Zhivotovsky L.A. 2005. DNA markers in forensic medical examination: The necessity to develop a Russian population database on “forensic” DNA markers. Med. Genet. 4, 4–187.
Efremov I.A., Zayats M.V., Ivanov P.L. 1998. Expert evaluation of molecular genetic systems based on HUMvWII and D6S366 tetranucleotide tandem repeats. Sud. Med. Ekspert. 2, 33–37.
Chistyakov D.A., Gavrilov D.K., Ovchinnikov I.V., Nosikov V.V. 1993. Use of polymerase chain reaction for allele distribution analysis of variable-number tandem repeats among 120 unrelated Russian individuals living in Moscow. Mol. Biol. (Moscow). 27, 745–820.
Kornienko I.V., Zemskova E.Yu., Frolova S.A., Iakushev V.V., Ivanov P.L. 2002. Allele polymorphism of molecular-genetic individualizing systems based on tetranucleotide tandem repeats LPL, vWA, and TH01 among the population of Russia. Sud. Med. Ekspert. 45, 12–14.
Pushkarev V.P., Rakhmanina L.V., Novikov P.I., Ivanov P.L. 2004. Studies of the allelic diversity in micro-satellite locus D16S539, F13B, FESFPS, TH01, and TROX in European population of Russia Ural region using capillary electrophoresis. Sud. Med. Ekspert. 47, 23–28.
Shorokhova D.A., Stepanov V.A., Udovenko Yu.D., Novoselov V.R., Puzyrev V.P. 2005. Genetic variation and discriminating rower of four DNA microsatellites in the Russian rorulation. Mol. Biol. (Moscow). 39, 845–850.
Kornienko I.V., Vodolazhsky D.I., Ivanov P.I. 2002. Genetic variation of the nine Profiler Plus loci in Russians. Int. J. Legal Med. 116, 309–311.
Malyarchuk B.A., Wozniak M., Czarny J., Derenko M.V., Grzybowski T., Miscicka-Sliwka D. 2007. Variation of 15 autosomal microsatellite DNA loci in the Russian population. Mol. Biol. (Moscow). 41, 1–4.
Zhivotovsky L.A., Malyarchuk B.A., Derenko M.V., Wozniak M, Grzybowski T. 2009. Developing STR databases on structured population: The native South Siberian population versus the Russian population. Forensic Sci. Int. Genet. 3, 111–116.
Zhivotovsky L.A., Akhmetova V.L., Fedorova S.A., Zhirkova V.V., Khusnutdinova E.K. 2009. An STR database on the Volga-Ural population. Forensic Sci. Int. Genet. 3, 133–136.
Khitrinskaya I.Yu., Stepanov V.A., Pusyrev V.P., Spiridonova M.G., Puzyrev K.V., Maksimova N.R., Nogovitsyna A.N. 2003. Genetic reculiarity of the Yakut population as inferred from autosomal loci. Mol. Biol. (Moscow). 37, 205–209.
Grigorieva L.V., Fedorova S.A., Mustafina O.E., Khusnutdinova E.K. 2006. VNTR-polymorphism of NOS3 gene and the analysis of associations with heart attack in population of Yakuts. Med. Genet. 11, 43–46.
Tarskaya L.A., Gogolev A.I., El’chinova G.I., Egorova A.G., Limborska S.A., et al, 2009. Etnicheskaya genomika yakutov (naroda Sakha) (Ethnogenomics of Yakuts, the Sakha People), Moscow: Nauka.
Fedorova S.A., Bermisheva M.A., Villems R., Maksimova N.R., Khusnutdinova E.K. 2003. Analysis of mitochondrial DNA lineages in Yakuts. Mol. Biol. (Moscow). 37, 544–553.
Fedorova S.A. 2008. Geneticheskie portrety narodov Respubliki Sakha (Yakutiya): analiz linii mitokhondrial’noi DNK i Y-khromosomy (Genetic Portraits of Indigenous Nations of Sakha (Yakutia): Analysis of mtDNA and Y-Chromosome Lineages), Yakutsk: Yakut. Nauchn. Tsentr Sib. Otd. Ross. Akad. Nauk.
Puzyrev V.P., Stepanov V.A., Golubenko M.V., Puzyrev K.V., Maximova N.R., Kharkov V.N., Spiridonova M.G., Nogovitsina A.N. 2003. MtDNA and Y-chromosome lineages in the Yakut population. Russ. J. Genet. 39, 816–822.
Pakendorf B., Novgorodov I.N., Osakovskij V.L., et al. 2006. Investigating the effects of prehistoric migrations in Siberia: Genetic variation and the origins of Yakuts. Hum. Genet. 120, 334–353.
Tereba A. 1999. Profiles in DNA. 3: Tools for Analysis of Population Statistics. Promega Corporation; http://www.promega.com/geneticidtools/powersats/
Bermisheva M.A., Petrova N.V., Zinchenko R.A., Timkovskaya E.E., Malyshev P.Yu, Gavrilina S.G., Ginter E.K., Khusnutdinova E.K. 2007. Population study of the Udmurt population: Analysis of ten polymorphic DNA loci of the nuclear genome. Russ. J. Genet. 43, 551–562.
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Original Russian Text © V.V. Zhirkova, S.A. Fedorova, V.L. Akhmetova, L.A. Zhivotovsky, E.K. Khusnutdinova, 2011, published in Molekulyarnaya Biologiya, 2011, Vol. 45, No. 2, pp. 249–257.
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Zhirkova, V.V., Fedorova, S.A., Akhmetova, V.L. et al. Allelic polymorphism of six microsatellite DNA Loci in populations of Sakha (Yakutia). Mol Biol 45, 221–228 (2011). https://doi.org/10.1134/S0026893311020221
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DOI: https://doi.org/10.1134/S0026893311020221